Invention Grant
US08664228B2 3,5-diamino-6-chloro-pyrazine-2-carboxylic acid derivatives and their use as epithelial sodium channel blockers for the treatment of airway diseases
有权
3,5-二氨基-6-氯 - 吡嗪-2-羧酸衍生物及其作为用于治疗气道疾病的上皮钠通道阻滞剂的用途
- Patent Title: 3,5-diamino-6-chloro-pyrazine-2-carboxylic acid derivatives and their use as epithelial sodium channel blockers for the treatment of airway diseases
- Patent Title (中): 3,5-二氨基-6-氯 - 吡嗪-2-羧酸衍生物及其作为用于治疗气道疾病的上皮钠通道阻滞剂的用途
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Application No.: US12990905Application Date: 2009-05-11
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Publication No.: US08664228B2Publication Date: 2014-03-04
- Inventor: Stephen Paul Collingwood , Catherine Howsham , Thomas Anthony Hunt
- Applicant: Stephen Paul Collingwood , Catherine Howsham , Thomas Anthony Hunt
- Applicant Address: CH Basel
- Assignee: Novartis AG
- Current Assignee: Novartis AG
- Current Assignee Address: CH Basel
- Agent Mark W. Milstead
- Priority: EP08156060 20080513
- International Application: PCT/EP2009/055657 WO 20090511
- International Announcement: WO2009/138378 WO 20091119
- Main IPC: A61K31/4965
- IPC: A61K31/4965
Abstract:
A compound of Formula I in free or salt or solvate form, where R1, R2, R3, R4, R5, R6, R7, R8 and R9 have the meanings as indicated in the specification, is useful for treating diseases which respond to the blockade of the epithelial sodium channel. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.
Public/Granted literature
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