Invention Grant
US08664227B2 Dual-acting thiophene, pyrrole, thiazole and furan antihypertensive agents
有权
双作用噻吩，吡咯，噻唑和呋喃抗高血压药
- Patent Title: Dual-acting thiophene, pyrrole, thiazole and furan antihypertensive agents
- Patent Title (中): 双作用噻吩，吡咯，噻唑和呋喃抗高血压药
-
Application No.: US13910696Application Date: 2013-06-05
-
Publication No.: US08664227B2Publication Date: 2014-03-04
- Inventor: Paul R. Fatheree , Robert Murray McKinnell
- Applicant: Paul R. Fatheree , Robert Murray McKinnell
- Applicant Address: US CA South San Francisco
- Assignee: Theravance, Inc.
- Current Assignee: Theravance, Inc.
- Current Assignee Address: US CA South San Francisco
- Agent Jeffrey A. Hagenah; Shelley Eblerle
- Main IPC: A61K31/497
- IPC: A61K31/497 ; A61K31/4436
Abstract:
In one aspect, the invention relates to compounds having the formula: wherein: Ar, Z, R3, R4 and R5 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have AT1 receptor antagonist activity and neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.
Public/Granted literature
- US20130267539A1 DUAL-ACTING THIOPHENE, PYRROLE, THIAZOLE AND FURAN ANTIHYPERTENSIVE AGENTS Public/Granted day:2013-10-10
Information query
IPC分类:
