Invention Grant
US08664216B2 Spiro-5,6-dihydro-4H-2,3,5,10b-tetraaza-benzo[e]azulenes
有权
螺-5,6-二氢-4H-2,3,5,10b-四氮杂 - 苯并[e]薁
- Patent Title: Spiro-5,6-dihydro-4H-2,3,5,10b-tetraaza-benzo[e]azulenes
- Patent Title (中): 螺-5,6-二氢-4H-2,3,5,10b-四氮杂 - 苯并[e]薁
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Application No.: US12613554Application Date: 2009-11-06
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Publication No.: US08664216B2Publication Date: 2014-03-04
- Inventor: Caterina Bissantz , Erwin Goetschi , Roland Jakob-Roetne , Raffaello Masciadri , Emmanuel Pinard , Hasane Ratni , Mark Rogers-Evans , Patrick Schnider
- Applicant: Caterina Bissantz , Erwin Goetschi , Roland Jakob-Roetne , Raffaello Masciadri , Emmanuel Pinard , Hasane Ratni , Mark Rogers-Evans , Patrick Schnider
- Applicant Address: US NJ Nutley
- Assignee: Hoffmann-La Roche Inc.
- Current Assignee: Hoffmann-La Roche Inc.
- Current Assignee Address: US NJ Nutley
- Priority: EP08169028 20081113
- Main IPC: A61P9/00
- IPC: A61P9/00 ; A61K31/55 ; C07D487/12
![Spiro-5,6-dihydro-4H-2,3,5,10b-tetraaza-benzo[e]azulenes](/abs-image/US/2014/03/04/US08664216B2/abs.jpg.150x150.jpg)
Abstract:
The present invention is concerned with spiro-dihydrotetraazabenzoazulenes, i.e. spiro-5,6-dihydro-4H-2,3,5,10b-tetraaza-benzo[e]azulenes of formula I wherein R1, R2, R3, X, Y, Z, m and n are as described herein. The compounds according to the invention act as V1a receptor modulators and are useful as therapeutics acting peripherally and centrally in the conditions of dysmenorrhea, male or female sexual dysfunction, hypertension, chronic heart failure, inappropriate secretion of vasopressin, liver cirrhosis, nephrotic syndrome, anxiety, depressive disorders, obsessive compulsive disorder, autistic spectrum disorders, schizophrenia, and aggressive behavior.
Public/Granted literature
- US20100120751A1 SPIRO-5,6-DIHYDRO-4H-2,3,5,10B-TETRAAZA-BENZO[E]AZULENES Public/Granted day:2010-05-13
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