Invention Grant
US08664210B2 Aminooxime derivatives of 2- and/or 4-substituted androstanes and androstenes as medicaments for cardiovascular disorders
失效
作为心血管疾病药物的2-和/或4-取代的雄甾烷和雄激素的氨基肟衍生物
- Patent Title: Aminooxime derivatives of 2- and/or 4-substituted androstanes and androstenes as medicaments for cardiovascular disorders
- Patent Title (中): 作为心血管疾病药物的2-和/或4-取代的雄甾烷和雄激素的氨基肟衍生物
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Application No.: US12680988Application Date: 2008-09-18
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Publication No.: US08664210B2Publication Date: 2014-03-04
- Inventor: Alberto Cerri , Giuseppe Bianchi , Giorgio Fedrizzi , Patrizia Ferrari , Mauro Gobbini , Marco Torri , Giuseppe Marazzi , Walter Cabri
- Applicant: Alberto Cerri , Giuseppe Bianchi , Giorgio Fedrizzi , Patrizia Ferrari , Mauro Gobbini , Marco Torri , Giuseppe Marazzi , Walter Cabri
- Applicant Address: IT Rome
- Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
- Current Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
- Current Assignee Address: IT Rome
- Agency: Lucas & Mercanti, LLP
- Priority: EP07118362 20071012
- International Application: PCT/EP2008/062483 WO 20080918
- International Announcement: WO2009/047101 WO 20090416
- Main IPC: A61K31/58
- IPC: A61K31/58 ; C07J41/00
Abstract:
New aminooxime derivatives at position 3 of 2- and/or 4-substituted androstanes and androstenes, processes for their preparation, and to pharmaceutical compositions containing them for the treatment of cardiovascular disorders, such as heart failure and hypertension. In particular compounds having the general formula (I) are described, where the radicals have the meanings described in detail in the application.
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