Invention Grant
- Patent Title: SPANX-B polypeptides and their use
- Patent Title (中): SPANX-B多肽及其用途
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Application No.: US13203042Application Date: 2010-02-26
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Publication No.: US08664183B2Publication Date: 2014-03-04
- Inventor: Bira Arya , Vladimir L. Larionov
- Applicant: Bira Arya , Vladimir L. Larionov
- Applicant Address: US DC Washington
- Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
- Current Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
- Current Assignee Address: US DC Washington
- Agency: Klarquist Sparkman, LLP
- International Application: PCT/US2010/025633 WO 20100226
- International Announcement: WO2010/099472 WO 20100902
- Main IPC: A61K38/00
- IPC: A61K38/00 ; A61K38/04 ; A61K38/08 ; A61K38/10 ; C07K9/00 ; C12N1/21 ; C12N5/10 ; C12N15/11 ; C12N15/63
Abstract:
It is disclosed herein that SPANX-B is uniquely expressed in a number of human tumors and that SPANX-B is an immunogenic antigen that is recognized by human T cells inducing helper CD4+ and cytolytic CD8+ T cell responses. Specific SPANX-B polypeptides and polynucleotides are disclosed that can be used to generate an immune response. In several embodiments, these polypeptides can be used for the treatment of a variety of cancers, including melanoma, colon carcinoma, ovarian cancer, breast cancer, myeloma, lung carcinoma and renal cancer.
Public/Granted literature
- US20110318374A1 SPANX-B POLYPEPTIDES AND THEIR USE Public/Granted day:2011-12-29
Information query
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