Invention Grant
US08663945B2 Methods of producing anti-TNF-alpha antibodies in mammalian cell culture
有权
在哺乳动物细胞培养物中产生抗TNF-α抗体的方法
- Patent Title: Methods of producing anti-TNF-alpha antibodies in mammalian cell culture
- Patent Title (中): 在哺乳动物细胞培养物中产生抗TNF-α抗体的方法
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Application No.: US13308075Application Date: 2011-11-30
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Publication No.: US08663945B2Publication Date: 2014-03-04
- Inventor: Itzcoatl A. Pla , Joseph C. Matuck , John C. Fann , Christof Schulz , Nicole A. Roy , David F. Bruton , James McIntire , David Chang Yu-Hsiang , Thomas Seewoester
- Applicant: Itzcoatl A. Pla , Joseph C. Matuck , John C. Fann , Christof Schulz , Nicole A. Roy , David F. Bruton , James McIntire , David Chang Yu-Hsiang , Thomas Seewoester
- Applicant Address: US IL North Chicago
- Assignee: AbbVie Inc
- Current Assignee: AbbVie Inc
- Current Assignee Address: US IL North Chicago
- Agency: McCarter & English, LLP
- Agent Cristin H. Cowles
- Main IPC: C12Q1/54
- IPC: C12Q1/54 ; C12Q1/02 ; C12P21/06 ; C12P21/04 ; C12N5/07 ; C12N5/10 ; C12N5/00 ; C12N5/02
Abstract:
The invention describes improved methods and compositions for producing a recombinant protein, e.g., an antibody, in mammalian cell culture. In addition, the invention provides improved cell culture media, including improved production media, feed solutions, and combination feeds, which may be used to improve protein productivity in mammalian cell culture.
Public/Granted literature
- US20120077213A1 CELL CULTURE IMPROVEMENTS Public/Granted day:2012-03-29
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