Invention Grant
- Patent Title: Means and methods for the determination of the amount of neurotoxin polypeptide and of its catalytic and proteolytic activities
- Patent Title (中): 用于测定神经毒素多肽的量及其催化和蛋白水解活性的方法和方法
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Application No.: US13138948Application Date: 2010-04-23
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Publication No.: US08663942B2Publication Date: 2014-03-04
- Inventor: Michael Pfeil , Josef Friedrich
- Applicant: Michael Pfeil , Josef Friedrich
- Applicant Address: DE Frankfurt am Main
- Assignee: Merz Pharma GmbH & Co. KGaA
- Current Assignee: Merz Pharma GmbH & Co. KGaA
- Current Assignee Address: DE Frankfurt am Main
- Agency: Hueschen and Sage
- Priority: EP09158788 20090427
- International Application: PCT/EP2010/055432 WO 20100423
- International Announcement: WO2010/124998 WO 20101104
- Main IPC: G01N33/53
- IPC: G01N33/53 ; G01N33/536 ; G01N33/566 ; C07K16/00
Abstract:
The present invention pertains to the field of tools for ensuring manufacture of polypeptides and quality control. Specifically, it relates to a method for determining the amount of processed (active) neurotoxin polypeptides in a solution comprising processed neurotoxin polypeptides and partially processed or unprocessed neurotoxin polypeptides. The present invention further relates to a device for determining the amount of neurotoxin polypeptides and a kit adapted to carry out the method of the present invention.
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