Invention Grant
US08663653B2 Efficient cell culture system for hepatitis C virus genotype 2B
失效
丙型肝炎病毒基因型2B的高效细胞培养系统
- Patent Title: Efficient cell culture system for hepatitis C virus genotype 2B
- Patent Title (中): 丙型肝炎病毒基因型2B的高效细胞培养系统
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Application No.: US13059130Application Date: 2009-07-24
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Publication No.: US08663653B2Publication Date: 2014-03-04
- Inventor: Judith M. Gottwein , Maria Lisa Knudsen , Troels Kasper Høyer Scheel , Jens Bukh
- Applicant: Judith M. Gottwein , Maria Lisa Knudsen , Troels Kasper Høyer Scheel , Jens Bukh
- Applicant Address: DK Hvidovre
- Assignee: Hvidovre Hospital
- Current Assignee: Hvidovre Hospital
- Current Assignee Address: DK Hvidovre
- Agency: Thompson Coburn LLP
- Agent Charles P. Romano
- Priority: EP08162466 20080815
- International Application: PCT/DK2009/050189 WO 20090724
- International Announcement: WO2010/017818 WO 20100218
- Main IPC: A61K39/12
- IPC: A61K39/12 ; A61K39/29 ; C12Q1/70 ; C12N15/00 ; C12N5/071 ; C12N1/20
Abstract:
The present inventors developed hepatitis C virus 2b/2a intergenotypic recombinants in which the JFH1 structural genes (Core, E1 and E2), p7 and the complete NS2 were replaced by the corresponding genes of the genotype 2b reference strain J8. Sequence analysis of recovered 2b/2a recombinants from 2 transfection experiments revealed that 2b/2a was genetically stable. Conclusion: The developed 2b/2a viruses provide a robust in vitro tool for research in HCV genotype 2b, including vaccine studies and functional analysis.
Public/Granted literature
- US20110294194A1 EFFICIENT CELL CULTURE SYSTEM FOR HEPATITIS C VIRUS GENOTYPE 2B Public/Granted day:2011-12-01
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