Invention Grant
US08663624B2 Adeno-associated virus virions with variant capsid and methods of use thereof
有权
具有变体衣壳的腺相关病毒颗粒及其使用方法
- Patent Title: Adeno-associated virus virions with variant capsid and methods of use thereof
- Patent Title (中): 具有变体衣壳的腺相关病毒颗粒及其使用方法
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Application No.: US13253760Application Date: 2011-10-05
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Publication No.: US08663624B2Publication Date: 2014-03-04
- Inventor: David V. Schaffer , Ryan R. Klimczak , James T. Koerber , John G. Flannery
- Applicant: David V. Schaffer , Ryan R. Klimczak , James T. Koerber , John G. Flannery
- Applicant Address: US CA Oakland
- Assignee: The Regents of the University of California
- Current Assignee: The Regents of the University of California
- Current Assignee Address: US CA Oakland
- Agency: Bozicevic, Field & Francis LLP.
- Agent Paula A. Borden
- Main IPC: A01N63/00
- IPC: A01N63/00 ; A01N65/00
Abstract:
The present disclosure provides adeno-associated virus (AAV) virions with altered capsid protein, where the AAV virions exhibit greater infectivity of retinal cells compared to wild-type AAV. The present disclosure further provides methods of delivering a gene product to a retinal cell in an individual, and methods of treating ocular disease.
Public/Granted literature
- US20120164106A1 ADENO-ASSOCIATED VIRUS VIRIONS WITH VARIANT CAPSID AND METHODS OF USE THEREOF Public/Granted day:2012-06-28
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