An endoscope cleaning sheath includes a flexible tube body that is mounted to an insertion portion having a bending portion included in an endoscope, and that has a plurality of through-holes parallel to a longitudinal axis; and a cylindrical distal end nozzle that is provided at a distal end portion of the flexible tube body and that sprays at least one of a gas and a liquid at least at an observation window provided at a distal end portion of the insertion portion of the endoscope. The through-holes are a hole for an endoscope insertion portion through which the insertion portion of the endoscope is inserted, and at least a first fluid conduit that supplies gas and a second fluid conduit that supplies liquid. The first fluid conduit and the second fluid conduit are provided at positions in a direction that is different from a bending direction of the bending portion of the insertion portion that is inserted and disposed in the hole for an endoscope insertion portion. The flexible tube body includes a sheath bending portion that covers a circumference of the bending portion of the insertion portion that is inserted and disposed in the hole for an endoscope insertion portion. The sheath bending portion includes at least one concave portion or hole that decreases a bending resistance of the sheath bending portion to a resistance that is less than a bending resistance of the flexible tube body.