Techniques for transmitting reference signal and data using cyclic shifts of a base sequence are described. The base sequence may have good correlation properties, and different cyclic shifts of the base sequence may be orthogonal to one another. A user equipment (UE) may send at least one reference signal on assigned resources using at least one cyclic shift of the base sequence. The UE may send data on the assigned resources using at least one other cyclic shift of the base sequence. For each reference signal, the UE may modulate a cyclic shift of the base sequence with a known modulation symbol. For data, the UE may modulate each cyclic shift of the base sequence used for data with a data modulation symbol. Multiple UEs may share the same resources. Each UE may be assigned a different set of cyclic shifts among all cyclic shifts available for the resources.