Invention Grant
US08642758B2 Process for preparation of erlotinib and its pharmaceutically acceptable salts
有权
厄洛替尼及其药学上可接受的盐的制备方法
- Patent Title: Process for preparation of erlotinib and its pharmaceutically acceptable salts
- Patent Title (中): 厄洛替尼及其药学上可接受的盐的制备方法
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Application No.: US12593212Application Date: 2008-04-03
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Publication No.: US08642758B2Publication Date: 2014-02-04
- Inventor: Dharmaraj Ramachandra Rao , Rajendra Narayanrao Kankan
- Applicant: Dharmaraj Ramachandra Rao , Rajendra Narayanrao Kankan
- Applicant Address: IN Mumbai
- Assignee: Cipla Limited
- Current Assignee: Cipla Limited
- Current Assignee Address: IN Mumbai
- Agency: Conley Rose, P.C.
- Agent Rodney B. Carroll
- Priority: IN681MUM/2007 20070404
- International Application: PCT/GB2008/001186 WO 20080403
- International Announcement: WO2008/122776 WO 20081016
- Main IPC: C07D239/94
- IPC: C07D239/94
Abstract:
A process for the preparation of a salt of N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine comprising reacting a 4-halo-6,7-bis(2-methoxyethoxy) quinazoline with 3-aminophenyl acetylene or an acid salt thereof under acidic conditions to form the corresponding acid salt of N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine, the process optionally further comprising converting the acid salt of N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine to N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine.
Public/Granted literature
- US20100094004A1 Process for Preparation of Erlotinib and its Pharmaceutically Acceptable Salts Public/Granted day:2010-04-15
Information query
