Invention Grant
US08642045B2 Recombinant virus vector originating in HHV-6 or HHV-7, method of producing the same, method of transforming host cell using the same, host cell transformed thereby and gene therapy method using the same
有权
源自HHV-6或HHV-7的重组病毒载体，其制备方法，使用其转化宿主细胞的方法，由此转化的宿主细胞和使用其的基因治疗方法
- Patent Title: Recombinant virus vector originating in HHV-6 or HHV-7, method of producing the same, method of transforming host cell using the same, host cell transformed thereby and gene therapy method using the same
- Patent Title (中): 源自HHV-6或HHV-7的重组病毒载体，其制备方法，使用其转化宿主细胞的方法，由此转化的宿主细胞和使用其的基因治疗方法
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Application No.: US10570589Application Date: 2004-08-30
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Publication No.: US08642045B2Publication Date: 2014-02-04
- Inventor: Kazuhiro Konda
- Applicant: Kazuhiro Konda
- Applicant Address: JP Osaka
- Assignee: Virus Ikagaku Kenkyusho Inc.
- Current Assignee: Virus Ikagaku Kenkyusho Inc.
- Current Assignee Address: JP Osaka
- Agency: Edwards Wildman Palmer LLP
- Agent David G. Conlin
- Priority: JP2003-307335 20030829
- International Application: PCT/JP2004/012487 WO 20040830
- International Announcement: WO2005/021746 WO 20050310
- Main IPC: C12N15/00
- IPC: C12N15/00 ; C12N15/09 ; C12N15/11 ; C12N15/33 ; C12N15/36 ; C12N15/63
Abstract:
It is intended to provide a virus vector by which an exogenous nucleotide sequence can be inserted and easily transferred into a mammalian host cell and a gene encoded by the exogenous nucleotide sequence can be expressed in the host cell, and which has a low risk of pathogenicity and is appropriately usable in gene therapy of mammals. Namely, a recombinant vector originating in HHV-6 which has an exogenous nucleotide sequence in a portion corresponding to at least one region selected from the group consisting of U2, U3, U4, U5, U6, U7, U8, U24, and U25 regions of HHV-6; or a recombinant vector originating in HHV-7 which has an exogenous nucleotide sequence in a portion corresponding to at least one region selected from the group consisting of U2, U3, U4, U7, U8, U24, U24a, and U25 regions of HHV-7.
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