Invention Grant
US08642040B2 Methods for promoting myelination, neuronal survival and oligodendrocyte differentiation via administration of Sp35 or TrkA antagonists
有权
通过施用Sp35或TrkA拮抗剂促进髓鞘形成，神经元存活和少突胶质细胞分化的方法
- Patent Title: Methods for promoting myelination, neuronal survival and oligodendrocyte differentiation via administration of Sp35 or TrkA antagonists
- Patent Title (中): 通过施用Sp35或TrkA拮抗剂促进髓鞘形成，神经元存活和少突胶质细胞分化的方法
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Application No.: US12375117Application Date: 2007-07-24
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Publication No.: US08642040B2Publication Date: 2014-02-04
- Inventor: Sha Mi , Vincent Jung
- Applicant: Sha Mi , Vincent Jung
- Applicant Address: US MA Cambridge
- Assignee: Biogen Idec MA Inc.
- Current Assignee: Biogen Idec MA Inc.
- Current Assignee Address: US MA Cambridge
- Agency: Sterne, Kessler, Goldstein & Fox P.L.L.C.
- International Application: PCT/US2007/016589 WO 20070724
- International Announcement: WO2008/013782 WO 20080131
- Main IPC: A61K39/00
- IPC: A61K39/00
Abstract:
This invention relates to methods for promoting myelination, neuronal survival, and oligodendrocyte differentiation and treating demyelination and dysmyelination disease by the administration of a TrkA antagonist. The invention also relates to methods of inhibiting or decreasing Sp35 expression by the use of a TrkA antagonist. Additionally, the invention relates generally to methods for blocking Sp35 and TrkA interaction and inhibiting or decreasing TrkA phosphorylation by the administration of a Sp35 antagonist.
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