An uplink scheduling method by a terminal which performs a communication service according to a semi-persistent resource allocation scheme in a Base Station (BS) of a mobile communication system. The uplink scheduling method includes generating resource allocation control information including a particular field set to a value predetermined according to the semi-persistent resource allocation scheme, code-masking the particular field of the resource allocation control information by using a Cyclic Shift (CS) value for a Multi-User Multiple Input Multiple Output (MU-MIMO) operation of the terminal, configuring a transport block including the code-masked resource allocation control information; and transmitting the transport block to the terminal. Therefore, the MU-MIMO can be implemented even in a Semi-Persistent Scheduling (SPS) scheme. When the BS provides a VoIP service, service delay, which may occur due to lack of resources, does not occur, and resources can be immediately allocated.