Invention Grant
US08524894B2 Inhibitor compounds of 11-beta-hydroxysteroid dehydrogenase type 1
有权
11-β-羟基类固醇脱氢酶抑制剂化合物1型
- Patent Title: Inhibitor compounds of 11-beta-hydroxysteroid dehydrogenase type 1
- Patent Title (中): 11-β-羟基类固醇脱氢酶抑制剂化合物1型
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Application No.: US13375389Application Date: 2010-06-04
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Publication No.: US08524894B2Publication Date: 2013-09-03
- Inventor: Juan Lorenzo Catena Ruiz , Carme Serra Comas , Oscar Rey Puiggros , Albert Antolin Hernandez , Esther Monlleo Mas
- Applicant: Juan Lorenzo Catena Ruiz , Carme Serra Comas , Oscar Rey Puiggros , Albert Antolin Hernandez , Esther Monlleo Mas
- Applicant Address: ES Barcelona
- Assignee: Laboratorios Salvat, S.A.
- Current Assignee: Laboratorios Salvat, S.A.
- Current Assignee Address: ES Barcelona
- Agency: Cooper & Dunham
- Agent Gary J. Gershik
- Priority: ESP200901402 20090604
- International Application: PCT/ES2010/000258 WO 20100604
- International Announcement: WO2010/139827 WO 20101209
- Main IPC: C07D215/14
- IPC: C07D215/14 ; C07D217/04 ; C07D217/06 ; C07D217/08 ; C07D401/06 ; C07D401/12 ; C07D405/12 ; C07D409/12 ; C07D409/14 ; C07D413/06
Abstract:
The compounds of formula (I) are derived from perhydroquinoline and perhydroisoquinoline and are useful as active pharmaceutical ingredients for the prophylaxis or treatment of diseases caused by 11-beta-hydroxysteroid dehydrogenase type 1 (11-beta-HSD1) enzyme-associated disorders, such as glaucoma, elevated ocular pressure, metabolic disorders, obesity, metabolic syndrome, dyslipidemia, hypertension, diabetes, atherosclerosis, Cushing's syndrome, psoriasis, rheumatoid arthritis, cognitive disorders, Alzheimer's disease or neurodegeneration.
Public/Granted literature
- US20120071466A1 INHIBITOR COMPOUNDS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 Public/Granted day:2012-03-22
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