Invention Grant
US08524499B2 Regulatory sequences that direct gene expression to spinal motor neurons and uses thereof
有权
将基因表达引导到脊髓运动神经元的调节序列及其用途
- Patent Title: Regulatory sequences that direct gene expression to spinal motor neurons and uses thereof
- Patent Title (中): 将基因表达引导到脊髓运动神经元的调节序列及其用途
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Application No.: US10984406Application Date: 2004-11-09
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Publication No.: US08524499B2Publication Date: 2013-09-03
- Inventor: Steven A. Goldman , Takahiro Nakano
- Applicant: Steven A. Goldman , Takahiro Nakano
- Applicant Address: US NY Ithaca
- Assignee: Cornell Research Foundation, Inc.
- Current Assignee: Cornell Research Foundation, Inc.
- Current Assignee Address: US NY Ithaca
- Agency: LeClairRyan, a Professional Corporation
- Main IPC: C12N15/86
- IPC: C12N15/86 ; C12N15/12 ; C12N15/00
Abstract:
The present invention relates to an enhancer which functions only in human brain and/or spinal cord motor neurons, where the enhancer comprises a nucleotide sequence of SEQ ID NO: 5, SEQ ID NO: 10, or SEQ ID NO: 16. The enhancer can be utilized as part of a nucleic acid construct which also has a nucleic acid encoding a marker protein or a therapeutic protein, a 3′ control region, and, optionally, a basal promoter, where these components are positioned with respect to one another to permit expression of the marker protein or the therapeutic protein. The enhancer of the present invention is useful in a method of isolating an enriched or purified population of motor neurons from a mixed population of human brain and/or spinal cells. In addition, the enhancer of the present invention can be used in a method of therapeutically targeting motor neurons.
Public/Granted literature
- US20050129672A1 Regulatory sequences that direct gene expression to spinal motor neurons and uses thereof Public/Granted day:2005-06-16
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