Disclosed herein are systems and methods for controlling access to content, and/or regions thereof, as well as controlling access to annotations to the content, or regions thereof. An audience can be specified for a region of content and one or more associated annotations. In response to a request for a content region, a content region definition, an audience definition for the content region, and at least one annotation for the content region and audience can be obtained, and the content region and the at least one annotation can be transmitted in response to the request if it is determined that the request is from a member of the audience, so that the content region and annotation can be experienced at an audience member's device.