The present invention is directed in general to a system and method that employs radiological localization ontology to localize specified and modeled radiological domain knowledge. A system and method are provided that allows for consulting the ontology in the context of the model the ontology fulfills. The result of consulting the ontology will be localized radiological information based on information provided in the consultation. Even further, such result is validated, identified and classified radiological information that is based on information provided in the consultation. By consulting the ontology the system is also able to translate designated radiological information from one localized representation to another and consult a language independent radiological domain knowledge.