Invention Grant
US08501757B2 Substituted phenylamine carboxamide analogs as mGluR5 negative allosteric modulators and methods of making and using the same
失效
取代的苯胺甲酰胺类似物作为mGluR5负变构调节剂及其制备和使用方法
- Patent Title: Substituted phenylamine carboxamide analogs as mGluR5 negative allosteric modulators and methods of making and using the same
- Patent Title (中): 取代的苯胺甲酰胺类似物作为mGluR5负变构调节剂及其制备和使用方法
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Application No.: US12885420Application Date: 2010-09-17
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Publication No.: US08501757B2Publication Date: 2013-08-06
- Inventor: P. Jeffrey Conn , Craig W. Lindsley , Kyle A. Emmitte , Charles David Weaver , Alice L. Rodriguez , Andrew S. Felts , Carrie K. Jones , Brittney S. Bates , Brian A. Chauder
- Applicant: P. Jeffrey Conn , Craig W. Lindsley , Kyle A. Emmitte , Charles David Weaver , Alice L. Rodriguez , Andrew S. Felts , Carrie K. Jones , Brittney S. Bates , Brian A. Chauder
- Applicant Address: US TN Nashville
- Assignee: Vanderbilt University
- Current Assignee: Vanderbilt University
- Current Assignee Address: US TN Nashville
- Agency: Clark & Elbing LLP
- Main IPC: A61K31/505
- IPC: A61K31/505 ; A61K31/44 ; C07D239/02 ; C07D403/12 ; C07D401/12 ; C07D213/62 ; A61K31/4965
Abstract:
Disclosed are negative allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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