Invention Grant
US08501740B2 Methods of treatment of opioid tolerance, physical dependence, pain and addiction with inhibitors of certain growth factor receptors
失效
用某些生长因子受体的抑制剂治疗阿片样物质耐受性，身体依赖性，疼痛和成瘾的方法
- Patent Title: Methods of treatment of opioid tolerance, physical dependence, pain and addiction with inhibitors of certain growth factor receptors
- Patent Title (中): 用某些生长因子受体的抑制剂治疗阿片样物质耐受性，身体依赖性，疼痛和成瘾的方法
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Application No.: US12682064Application Date: 2008-10-08
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Publication No.: US08501740B2Publication Date: 2013-08-06
- Inventor: Howard Gutstein
- Applicant: Howard Gutstein
- Applicant Address: US TX Austin
- Assignee: Board of Regents, The University of Texas System
- Current Assignee: Board of Regents, The University of Texas System
- Current Assignee Address: US TX Austin
- Agency: Parker Highlander PLLC
- International Application: PCT/US2008/079198 WO 20081008
- International Announcement: WO2009/048947 WO 20090416
- Main IPC: A61K31/497
- IPC: A61K31/497 ; A01N43/54 ; C07D239/42 ; C07D401/04 ; C07D239/00 ; C07D239/02 ; C07D403/00 ; C07D405/00 ; C07D409/00
Abstract:
Methods of preventing the development and reversing or partially reversing opioid tolerance in a subject are provided herein. Such methods include the step of administering to a subject in need thereof a therapeutically effective amount of a PDGFR modulator or EGFR modulator alone or together with an opiate analgesic. The methods can also be used for the treatment of refractory neuropathic pain, physical dependence or addiction.
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