Invention Grant
US08501236B2 Method for producing a crystalline tableting additive, additive thus obtained and use thereof
有权
制造结晶压片添加剂的方法,由此获得的添加剂及其用途
- Patent Title: Method for producing a crystalline tableting additive, additive thus obtained and use thereof
- Patent Title (中): 制造结晶压片添加剂的方法,由此获得的添加剂及其用途
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Application No.: US13408359Application Date: 2012-02-29
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Publication No.: US08501236B2Publication Date: 2013-08-06
- Inventor: Klaas Daniel Kussendrager , Henricus Alphonsus Maria Van Den Biggelaar
- Applicant: Klaas Daniel Kussendrager , Henricus Alphonsus Maria Van Den Biggelaar
- Applicant Address: NL Zaltbommel
- Assignee: Campina B.V.
- Current Assignee: Campina B.V.
- Current Assignee Address: NL Zaltbommel
- Agency: Foley & Lardner LLP
- Agent Gilberto M. Villacorta; Sunit Talapatra
- Priority: NL1015752 20000720
- Main IPC: A61K9/14
- IPC: A61K9/14

Abstract:
A method for producing a tableting additive, which method comprises providing a spray dried tableting additive in particulate form which particles at leas partially consist of amorphous additive material and at least partially of crystalline additive material; and crystallising the amorphous additive material by subjecting the particles for a short time and under agitation to a temperature between 30 and 100° C. at a relative humidity between 60 and 25%. More in particular, the relationship between relative humidity and temperature is defined by the formula: % relative humidity=218-47*Ln(T(° C.)), wherein T(° C.) is the temperature to which the particles are subjected.
Public/Granted literature
- US20120220764A1 METHOD FOR PRODUCING A CRYSTALLINE TABLETING ADDITIVE, ADDITIVE THUS OBTAINED AND USE THEREOF Public/Granted day:2012-08-30
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