Invention Grant
- Patent Title: Methods of reducing eosinophil levels
- Patent Title (中): 减少嗜酸性粒细胞水平的方法
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Application No.: US13177221Application Date: 2011-07-06
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Publication No.: US08501176B2Publication Date: 2013-08-06
- Inventor: Masamichi Koike , George L. Spitalny , Alistair Wheeler , Barbara White
- Applicant: Masamichi Koike , George L. Spitalny , Alistair Wheeler , Barbara White
- Applicant Address: US MD Gaithersburg US NJ Princeton
- Assignee: MedImmune, LLC,BIOWA, Inc.
- Current Assignee: MedImmune, LLC,BIOWA, Inc.
- Current Assignee Address: US MD Gaithersburg US NJ Princeton
- Main IPC: A61K39/395
- IPC: A61K39/395 ; C07K16/28
Abstract:
The present invention relates to a method of reducing the numbers of eosinophils in a human subject comprising administration to a subject an IL-5R binding molecule that comprises (a) a region that specifically binds to the IL-5R and (b) an immunoglobulin Fc region. In a specific embodiment, a method of the invention reduces the number of eosinophils in blood, bone marrow, gastrointestinal tract (e.g. esophagus, stomach, small intestine and colon), or lung.
Public/Granted literature
- US20120148575A1 Methods Of Reducing Eosinophil Levels Public/Granted day:2012-06-14
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