An endoscopic instrument for performing surgical procedures. The instrument includes an elongate member having a distal end for insertion into a patient's body and a proximal end opposite the distal end. The member has a distal portion adjacent the distal end and a central portion adjacent the distal portion. The distal portion has a first mechanical stiffness of a stiffness type selected from a tensile stiffness, a compressive stiffness and/or a bending stiffness. The central portion has a second mechanical stiffness of the stiffness type of the first mechanical stiffness. The first mechanical stiffness is different from the second mechanical stiffness.