An apparatus and a method for Automatic Repeat reQuest (ARQ) feedback in a wireless communication system are provided. A method for the ARQ feedback at a receiving end includes when receiving an ARQ block from the transmitting end, checking for error in the ARQ block, when the ARQ block has no error, initializing and driving a timer used for determining whether to perform the ARQ feedback according to reception of a next ARQ block, when receiving the next ARQ block without error before the timer expires, initializing and driving the timer, and when the timer expires, performing the ARQ feedback in relation to at least one ARQ block received without error.