A system and method are provided for automatically correlating neurological activity to a predetermined physiological response. The system includes at least one sensor operable to sense signals indicative of the neurological activity, and a processing engine coupled to the sensor. The processing engine is operable in a first system mode to execute a simultaneous sparse approximation jointly upon a group of signals sensed by the sensor to generate signature information corresponding to the predetermined physiological response. The system further includes a detector coupled to the sensors, which is operable in a second system mode to monitor the sensed signals. The detector generates upon selective detection according to the signature information a control signal for actuating a control action according to the predetermined physiological response.