Power amplifiers (PAs) using a Doherty or other power output level sensitive configuration have been employed for several years in telecommunications (as well as other applications) to take advantage of efficiency gains. For many of these applications, baseband signals are predistorted to compensate for nonlinearities in the PAs, but because there is a “switching event” in a Doherty-type amplifier (for example), the nonlinearities become dynamically varying. As a result, digital predistortion (DPD) becomes increasingly difficult to perform. Here, DPD modules are provided that adapt to changes in dynamically varying PAs based on a determination of the average power or other relevant metric prior to transmission.