Described herein are systems and methods for stress avoidance and stress compensation in low power Liquid Crystal Displays (LCDs). In an exemplary embodiment, two or more transistors in series are used to hold charge on an LCD pixel. To avoid negative stress on the transistors, the transistors are alternately driven to an “off” state so that no one transistor sees a long “off” time. In another embodiment, stress on transistors of a display circuit are measured and controlled negative stress is applied to the transistors to compensate for the measured stress.