Invention Grant
US08476485B2 Non-human animal model for amyotrophic lateral sclerosis (ALS) with loss-of-TDP-43 function
有权
具有TDP-43丧失功能的肌萎缩性侧索硬化（ALS）的非人动物模型
- Patent Title: Non-human animal model for amyotrophic lateral sclerosis (ALS) with loss-of-TDP-43 function
- Patent Title (中): 具有TDP-43丧失功能的肌萎缩性侧索硬化（ALS）的非人动物模型
-
Application No.: US13166147Application Date: 2011-06-22
-
Publication No.: US08476485B2Publication Date: 2013-07-02
- Inventor: Che-Kun James Shen , Lien-Szu Wu
- Applicant: Che-Kun James Shen , Lien-Szu Wu
- Applicant Address: TW Taipei
- Assignee: Academia Sinica
- Current Assignee: Academia Sinica
- Current Assignee Address: TW Taipei
- Agency: Intellectual Property Connections, Inc.
- Agent Hsiu-Ming Saunders
- Main IPC: A01K67/027
- IPC: A01K67/027 ; G01N33/00
Abstract:
A non-human animal model for amyotrophic lateral sclerosis (ALS) is disclosed. The animal model comprises a rodent whose spinal cord motor neurons have a loss of TAR-DNA binding protein-43 (TDP-43) function and phenotypes exhibit ALS-like symptoms. A method for identifying a candidate agent for treating, preventing and/or inhibiting ALS associated with a loss-of-function of TDP-43 is also disclosed.
Public/Granted literature
- US20110321179A1 NON-HUMAN ANIMAL MODEL FOR AMYOTROPHIC LATERAL SCLEROSIS (ALS) WITH LOSS-OF-TDP-43 FUNCTION Public/Granted day:2011-12-29
Information query
