Invention Grant
US08476457B2 Indole, indazole and benzimidazole arylamides as P2X3 and P2X2/3 antagonists
有权
吲哚，吲唑和苯并咪唑芳基酰胺，如P2X3和P2X2 / 3拮抗剂
- Patent Title: Indole, indazole and benzimidazole arylamides as P2X3 and P2X2/3 antagonists
- Patent Title (中): 吲哚，吲唑和苯并咪唑芳基酰胺，如P2X3和P2X2 / 3拮抗剂
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Application No.: US12820748Application Date: 2010-06-22
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Publication No.: US08476457B2Publication Date: 2013-07-02
- Inventor: Michael Patrick Dillon , Nancy Elisabeth Krauss
- Applicant: Michael Patrick Dillon , Nancy Elisabeth Krauss
- Applicant Address: US CA Palo Alto
- Assignee: Roche Palo Alto LLC
- Current Assignee: Roche Palo Alto LLC
- Current Assignee Address: US CA Palo Alto
- Agent Robert C. Hall
- Main IPC: C07D231/56
- IPC: C07D231/56 ; C07D213/26 ; C07D213/40 ; C07D403/12 ; C07D403/14
Abstract:
Compounds of the formula I: or a pharmaceutically acceptable salt thereof, wherein, X, Y, Z, R1, R2, R3, R4 and R5 are as defined herein. Also disclosed are methods of using the compounds for treating diseases associated with P2X3 and/or a P2X2/3 receptor antagonists and methods of making the compounds.
Public/Granted literature
- US20100324070A1 INDOLE, INDAZOLE AND BENZIMIDAZOLE ARYLAMIDES AS P2X3 AND P2X2/3 ANTAGONISTS Public/Granted day:2010-12-23
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