Invention Grant
- Patent Title: Process for the preparation of dimiracetam
- Patent Title (中): 制备二拉西坦的方法
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Application No.: US13811727Application Date: 2011-07-25
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Publication No.: US08476453B2Publication Date: 2013-07-02
- Inventor: Carlo Farina , Jacopo Roletto , Stefano Gobbato
- Applicant: Carlo Farina , Jacopo Roletto , Stefano Gobbato
- Applicant Address: CH Schlieren
- Assignee: Neurotune AG
- Current Assignee: Neurotune AG
- Current Assignee Address: CH Schlieren
- Agency: Wenderoth, Lind & Ponack, L.L.P.
- Priority: EP10170741 20100726
- International Application: PCT/EP2011/062767 WO 20110725
- International Announcement: WO2012/013640 WO 20120202
- Main IPC: C07D487/04
- IPC: C07D487/04
Abstract:
The invention relates to a method of manufacture of dimiracetam (2,5-dioxohexahydro-1 H-pyrrolo[1,2-a]imidazole), characterized in that a 4-oxo-butanoic acid ester is condensed with glycinamide in a one-pot reaction with a controlled pH. The reaction may be performed in aqueous solution or in an anhydrous lower alcohol solution.
Public/Granted literature
- US20130123509A1 PROCESS FOR THE PREPARATION OF DIMIRACETAM Public/Granted day:2013-05-16
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