Invention Grant
- Patent Title: Process for making modulators of cystic fibrosis transmembrane conductance regulator
- Patent Title (中): 制备囊性纤维化跨膜电导调节剂的方法
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Application No.: US12728173Application Date: 2010-03-19
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Publication No.: US08476442B2Publication Date: 2013-07-02
- Inventor: John DeMattei , Adam R. Looker , Bobbianna Neubert-Langille , Martin Trudeau , Stefanie Roeper , Michael P. Ryan , Dahrika Milfred Lao Yap , Brian R. Krueger , Peter D. J. Grootenhuis , Fredrick F. van Goor , Martyn C. Botfield , Gregor Zlokarnik
- Applicant: John DeMattei , Adam R. Looker , Bobbianna Neubert-Langille , Martin Trudeau , Stefanie Roeper , Michael P. Ryan , Dahrika Milfred Lao Yap , Brian R. Krueger , Peter D. J. Grootenhuis , Fredrick F. van Goor , Martyn C. Botfield , Gregor Zlokarnik
- Applicant Address: US MA Cambridge
- Assignee: Vertex Pharmaceutical Incorporated
- Current Assignee: Vertex Pharmaceutical Incorporated
- Current Assignee Address: US MA Cambridge
- Agency: Honigman Miller Schwartz and Cohn LLP
- Agent Christopher C. Forbes, Ph.D.; Jonathan P. O'Brien, Ph.D.
- Main IPC: C07D215/233
- IPC: C07D215/233 ; C07D215/00 ; C07D307/77 ; C07D307/00 ; A61K31/47
Abstract:
The invention provides a process for the preparation of a compound of Formula 1, comprising coupling a carboxylic acid of Formula 2 with an aniline of Formula 3 in the presence of a coupling agent.
Public/Granted literature
- US20100267768A1 PROCESS FOR MAKING MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR Public/Granted day:2010-10-21
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