Invention Grant
- Patent Title: Protein kinase modulators and method of use
- Patent Title (中): 蛋白激酶调节剂及其使用方法
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Application No.: US12952156Application Date: 2010-11-22
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Publication No.: US08476434B2Publication Date: 2013-07-02
- Inventor: Stephanie D. Geuns-Meyer , Brian L. Hodous , Stuart C. Chaffee , Paul Tempest , Ning Xi , Phillip R. Olivieri , Joseph L. Kim , Steven Bellon , Xiaotian Zhu , Yuan Cheng , Brian K. Albrecht , Vinod F. Patel , Victor J. Cee , Karina Romero , Hanh Nho Nguyen , Holly L. Deak , Rebecca E. Johnson
- Applicant: Stephanie D. Geuns-Meyer , Brian L. Hodous , Stuart C. Chaffee , Paul Tempest , Ning Xi , Phillip R. Olivieri , Joseph L. Kim , Steven Bellon , Xiaotian Zhu , Yuan Cheng , Brian K. Albrecht , Vinod F. Patel , Victor J. Cee , Karina Romero , Hanh Nho Nguyen , Holly L. Deak , Rebecca E. Johnson
- Applicant Address: US CA Thousand Oaks
- Assignee: Amgen Inc.
- Current Assignee: Amgen Inc.
- Current Assignee Address: US CA Thousand Oaks
- Agent G. Prabhakar Reddy
- Main IPC: C07D401/12
- IPC: C07D401/12 ; C07D401/14 ; C07D403/12 ; C07D403/14 ; A61K31/4427 ; A61K31/506 ; A61K31/54 ; A61P19/02 ; A61P35/00
Abstract:
The present invention relates to chemical compounds having a general formula I wherein A, B, D, E, G, H1-5 and R1-4 are defined herein, and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions related to the activities of these kinases. For example, the compounds are capable of modulating kinase enzymes thereby influencing the process of angiogenesis and treating angiogenesis-related diseases and other proliferative disorders, including cancer and inflammation. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of protein kinases.
Public/Granted literature
- US20110201602A1 PROTEIN KINASE MODULATORS AND METHOD OF USE Public/Granted day:2011-08-18
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