Invention Grant
US08476408B2 Unacylated ghrelin and analogs as therapeutic agents for vascular remodeling in diabetic patients and treatment of cardiovascular disease
有权
非甲酰化的生长素释放肽和类似物作为糖尿病患者血管重塑的治疗剂和心血管疾病的治疗
- Patent Title: Unacylated ghrelin and analogs as therapeutic agents for vascular remodeling in diabetic patients and treatment of cardiovascular disease
- Patent Title (中): 非甲酰化的生长素释放肽和类似物作为糖尿病患者血管重塑的治疗剂和心血管疾病的治疗
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Application No.: US12482882Application Date: 2009-06-11
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Publication No.: US08476408B2Publication Date: 2013-07-02
- Inventor: Maria Brizzi , Giampiero Muccioli , Ezio Ghigo
- Applicant: Maria Brizzi , Giampiero Muccioli , Ezio Ghigo
- Applicant Address: FR Ecully
- Assignee: Alize Pharma SAS
- Current Assignee: Alize Pharma SAS
- Current Assignee Address: FR Ecully
- Agency: Fish & Richardson P.C.
- Main IPC: C07K7/00
- IPC: C07K7/00
Abstract:
The present invention relates to a method for treating a cardiovascular disease, for increasing the number of circulating angiogenic cells (CAC) and/or improving the function of CAC and a method for improving vascular remodeling and/or neovascularisation. The method comprises administering to the subject a therapeutically effective amount of unacylated ghrelin or a polypeptide comprising the amino acid sequence set forth in SEQ ID NO: 1 or a fragment or analog thereof having the biological activity of SEQ ID NO: 1; and to pharmaceutical compositions comprising unacylated ghrelin or a polypeptide comprising the amino acid sequence set forth in SEQ ID NO: 1 or a fragment or analog thereof having the biological activity of SEQ ID NO: 1.
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