Invention Grant
- Patent Title: Neuregulin variants and methods of screening and using thereof
- Patent Title (中): 神经调节蛋白变体及其筛选和使用方法
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Application No.: US12095904Application Date: 2006-12-04
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Publication No.: US08476405B2Publication Date: 2013-07-02
- Inventor: Mingdong Zhou
- Applicant: Mingdong Zhou
- Applicant Address: CN Shanghai
- Assignee: Zensun (Shanghai) Science & Technology Ltd.
- Current Assignee: Zensun (Shanghai) Science & Technology Ltd.
- Current Assignee Address: CN Shanghai
- Agency: Jones Day
- International Application: PCT/CN2006/003240 WO 20061204
- International Announcement: WO2007/062594 WO 20070607
- Main IPC: A61K38/17
- IPC: A61K38/17 ; A61P25/00
Abstract:
The present invention provides polypeptide variants of neuregulin-1β (NRG-1β) that have enhanced or decreased binding affinity to ErbB3 and/or ErbB4. The invention also provides methods of screening and producing polypeptide variants of NRG-1β and methods of using polypeptide variants of NRG-1β for treating diseases.
Public/Granted literature
- US20090203595A1 NEUREGULIN VARIANTS AND METHODS OF SCREENING AND USING THEREOF Public/Granted day:2009-08-13
Information query
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