Invention Grant
- Patent Title: Pyridine and pyrazine derivative for the treatment of CF
- Patent Title (中): 吡啶和吡嗪衍生物用于治疗CF
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Application No.: US13544182Application Date: 2012-07-09
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Publication No.: US08476269B2Publication Date: 2013-07-02
- Inventor: Urs Baettig , Kamlesh Jagdis Bala , Emma Budd , Lee Edwards , Catherine Howsham , Glyn Alan Hughes , Darren Mark Legrand , Katrin Spiegel
- Applicant: Urs Baettig , Kamlesh Jagdis Bala , Emma Budd , Lee Edwards , Catherine Howsham , Glyn Alan Hughes , Darren Mark Legrand , Katrin Spiegel
- Applicant Address: CH Basel
- Assignee: Novartis AG
- Current Assignee: Novartis AG
- Current Assignee Address: CH Basel
- Agent Joshua Roth
- Main IPC: A61K31/5355
- IPC: A61K31/5355 ; A61K31/497 ; A61K31/4965 ; A61K31/4453 ; A61K31/454 ; A61K31/443 ; A61K31/444 ; A61K31/445 ; C07D213/22 ; C07D213/26 ; C07D211/06 ; C07D413/12 ; C07D213/61 ; C07D213/04 ; C07D241/16
Abstract:
The present invention provides pyridine and pyrazine derivatives which restore or enhance the function of mutant and/or wild type CFTR to treat cystic fibrosis, primary ciliary dyskinesia, chronic bronchitis, chronic obstructive pulmonary disease, asthma, respiratory tract infections, lung carcinoma, xerostomia and keratoconjunctivitis sire, or constipation (IBS, IBD, opioid induced). Pharmaceutical compositions comprising such derivatives are also encompassed.
Public/Granted literature
- US20120277232A1 Pyridine and Pyrazine Derivative for the Treatment of CF Public/Granted day:2012-11-01
Information query
