Invention Grant
US08476264B2 N-(3-(2-amino-6,6-difluoro-4,4A,5,6,7,7A-hexahydro-cyclopenta[E][1,3]oxazin-4-yl)-phenylamides as BACE1 inhibitors
有权
作为BACE1抑制剂的N-（3-（2-氨基-6,6-二氟-4,4A，5,6,7,7a-六氢 - 环戊二烯并[E] [1,3]恶嗪-4-基） - 苯基酰胺
![N-(3-(2-amino-6,6-difluoro-4,4A,5,6,7,7A-hexahydro-cyclopenta[E][1,3]oxazin-4-yl)-phenylamides as BACE1 inhibitors](/docs/US/2013-07-02/US08476264B2/abs.jpg.600x600.jpg)
- Patent Title: N-(3-(2-amino-6,6-difluoro-4,4A,5,6,7,7A-hexahydro-cyclopenta[E][1,3]oxazin-4-yl)-phenylamides as BACE1 inhibitors
- Patent Title (中): 作为BACE1抑制剂的N-（3-（2-氨基-6,6-二氟-4,4A，5,6,7,7a-六氢 - 环戊二烯并[E] [1,3]恶嗪-4-基） - 苯基酰胺
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Application No.: US13609304Application Date: 2012-09-11
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Publication No.: US08476264B2Publication Date: 2013-07-02
- Inventor: Hans Hilpert , Emmanuel Pinard , Thomas Woltering
- Applicant: Hans Hilpert , Emmanuel Pinard , Thomas Woltering
- Applicant Address: US NJ Nutley
- Assignee: Hoffmann-La Roche Inc.
- Current Assignee: Hoffmann-La Roche Inc.
- Current Assignee Address: US NJ Nutley
- Priority: EP11182172 20110921
- Main IPC: C07D265/08
- IPC: C07D265/08 ; C07D413/12 ; C07D417/12 ; A61K31/5355
![N-(3-(2-amino-6,6-difluoro-4,4A,5,6,7,7A-hexahydro-cyclopenta[E][1,3]oxazin-4-yl)-phenylamides as BACE1 inhibitors](/abs-image/US/2013/07/02/US08476264B2/abs.jpg.150x150.jpg)
Abstract:
The present invention provides N-(3-(2-amino-6,6-difluoro-4,4a,5,6,7,7a-hexahydro-cyclopenta[e][1,3]oxazin-4-yl)-phenyl)-amides of formula I having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease.
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