Invention Grant
US08476032B2 Complement factor H-based assays for serum bactericidal activity against Neisseria meningitidis
失效
用于脑膜炎奈瑟氏球菌血清杀菌活性的补体因子H-测定
- Patent Title: Complement factor H-based assays for serum bactericidal activity against Neisseria meningitidis
- Patent Title (中): 用于脑膜炎奈瑟氏球菌血清杀菌活性的补体因子H-测定
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Application No.: US12548316Application Date: 2009-08-26
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Publication No.: US08476032B2Publication Date: 2013-07-02
- Inventor: Dan M. Granoff , JoAnne Welsch , Sanjay Ram
- Applicant: Dan M. Granoff , JoAnne Welsch , Sanjay Ram
- Applicant Address: US CA Oakland IT Siena US MA Boston
- Assignee: Children's Hospital & Research Center Oakland,Novartis Vaccines and Diagnostics, SRL,The University of Massachusetts
- Current Assignee: Children's Hospital & Research Center Oakland,Novartis Vaccines and Diagnostics, SRL,The University of Massachusetts
- Current Assignee Address: US CA Oakland IT Siena US MA Boston
- Agency: Bozicevic, Field & Francis LLP
- Agent Carol L. Francis
- Main IPC: G01N33/554
- IPC: G01N33/554 ; G01N33/53
Abstract:
Assays for detection of bactericidal anti-Neisserial antibodies using a factor H polypeptide having a human amino acid sequence that mediates binding to Neisserial factor H binding protein (fHBp) are provided, as well as non-human animal models of Neisserial infection.
Public/Granted literature
- US20100240075A1 COMPLEMENT FACTOR H-BASED ASSAYS FOR SERUM BACTERICIDAL ACTIVITY AGAINST NEISSERIA MENINGITIDIS Public/Granted day:2010-09-23
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