Invention Grant
- Patent Title: Processes and compositions for methylation-based acid enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
- Patent Title (中): 用于非侵入性产前诊断的母体样品的甲基化酸富集的胎儿核酸的方法和组合物
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Application No.: US12561241Application Date: 2009-09-16
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Publication No.: US08476013B2Publication Date: 2013-07-02
- Inventor: Mathias Ehrich , Anders Olof Herman Nygren
- Applicant: Mathias Ehrich , Anders Olof Herman Nygren
- Applicant Address: US CA San Diego
- Assignee: Sequenom, Inc.
- Current Assignee: Sequenom, Inc.
- Current Assignee Address: US CA San Diego
- Agency: Grant Anderson LLP
- Main IPC: C12Q1/68
- IPC: C12Q1/68 ; C12P19/34
Abstract:
Provided are compositions and processes that utilize genomic regions differentially methylated between a mother and her fetus to separate, isolate or enrich fetal nucleic acid from a maternal sample. The compositions and processes described herein are useful for non-invasive prenatal diagnostics, including the detection of chromosomal aneuplodies.
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