Work units are transparently offloaded from a main processor to offload processing systems for execution. For a particular work unit, a suitable offload processing system is selected to execute the work unit. This includes determining the requirements of the work unit, including, for instance, the hardware and software requirements; matching those requirements against a set of offload processing systems with an arbitrary set of available resources; and determining if a suitable offload processing system is available. If a suitable offload processing system is available, the work unit is scheduled to execute on that offload processing system with no changes to the work unit itself. Otherwise, the work unit may execute on the main processor or wait to be executed on an offload processing system.