A system and method may allow automatic display of un-viewed images of an image stream, which may be produced by an ingestible capsule. A set of images acquired by an in-vivo device disposed within a body lumen is received by a receiver or workstation, and a portion of the set of images is selected for display as an image stream. The selected portion of images is displayed as a first image stream, and a complementary portion of the set of images is displayed as a second image stream. The complementary portion includes unselected images from the set of images, and/or images which are indicated as unviewed images. A graphical user interface is provided for selecting a viewing mode which is determined based on previously viewed images and users' review history.