Invention Grant
- Patent Title: Photobleaching and intermittency localization microscopy
- Patent Title (中): 漂白和间歇定位显微镜
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Application No.: US13578218Application Date: 2011-02-22
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Publication No.: US08445867B2Publication Date: 2013-05-21
- Inventor: Paul R. Selvin , Paul Dennis Simonson
- Applicant: Paul R. Selvin , Paul Dennis Simonson
- Applicant Address: US IL Urbana
- Assignee: Board of Trustees of the University of Illinois
- Current Assignee: Board of Trustees of the University of Illinois
- Current Assignee Address: US IL Urbana
- Agent Richard Aron Osman
- International Application: PCT/US2011/025750 WO 20110222
- International Announcement: WO2011/106323 WO 20110901
- Main IPC: G01J1/58
- IPC: G01J1/58

Abstract:
A method of image analysis creates super-resolution images from images with high densities of fluorophores by processing a movie in which the fluorescent molecules or particles are photobleaching or blinking. The method looks for the individual photobleaching events that can be located with high resolution (nm to tens of nanometers scale). The positions of the photobleaching or blinking events are then drawn in a composite image that is at a much higher resolution than the original fluorescence movie.
Public/Granted literature
- US20120313012A1 Photobleaching and Intermittency Localization Microscopy Public/Granted day:2012-12-13
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