Invention Grant
- Patent Title: Animal model having a chimeric human liver and susceptible to human hepatitis C virus infection
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Application No.: US13484073Application Date: 2012-05-30
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Publication No.: US08445745B2Publication Date: 2013-05-21
- Inventor: Norman M. Kneteman , D. Lorne Tyrrell , David Frederick Mercer
- Applicant: Norman M. Kneteman , D. Lorne Tyrrell , David Frederick Mercer
- Applicant Address: CA Edmonton, Alberta
- Assignee: KMT Hepatech, Inc.
- Current Assignee: KMT Hepatech, Inc.
- Current Assignee Address: CA Edmonton, Alberta
- Agency: Bozicevic, Field & Francis LLP
- Agent Carol L. Francis
- Main IPC: G01N33/00
- IPC: G01N33/00 ; A01K67/00 ; A01K67/033 ; A01K67/027
Abstract:
The present invention features a non-human animal model that is susceptible to infection by human hepatotrophic pathogens, particularly human hepatitis C virus (HCV). The model is based on a non-human, immunocompromised transgenic animal having a human-mouse chimeric liver, where the transgene provides for expression of a urokinase-type plasminogen activator in the liver. The invention also features methods for identifying candidate therapeutic agents, e.g., agents having antiviral activity against HCV infection. The animals of the invention are also useful in assessing toxicity of various agents, as well as the activity of agents in decreasing blood lipids.
Public/Granted literature
- US20120309032A1 Animal Model Having a Chimeric Human Liver and Suceptible to Human Hepatitis C Virus Infection Public/Granted day:2012-12-06
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