Invention Grant
- Patent Title: Inhibitors of BCL-2
- Patent Title (中): BCL-2抑制剂
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Application No.: US13218818Application Date: 2011-08-26
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Publication No.: US08445441B2Publication Date: 2013-05-21
- Inventor: Clark W. Distelhorst , Yiping Rong
- Applicant: Clark W. Distelhorst , Yiping Rong
- Applicant Address: US OH Cleveland
- Assignee: Case Western Reserve University
- Current Assignee: Case Western Reserve University
- Current Assignee Address: US OH Cleveland
- Agency: Tarolli, Sundheim, Covell & Tummino LLP
- Main IPC: A61K38/10
- IPC: A61K38/10 ; A61K38/16 ; C07K7/08 ; C07K14/00
Abstract:
A purified polypeptide for inhibiting binding of BCL-2 to IP3 receptors includes an amino acid sequence consisting of about 10 to 80 amino acids. The amino acid sequence has a sequence identity at least 90% homologous to a portion of SEQ ID NO:1. The polypeptide inhibits binding of Bcl-2 to IP3 receptors of cells that express IP3R and Bcl-2 and induces apoptosis in a cell.
Public/Granted literature
- US20110312896A1 INHIBITORS OF BCL-2 Public/Granted day:2011-12-22
Information query
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