Invention Grant
US08445235B2 Process for the production of the Actinobacillus pleuropneumoniae toxins APXI or APXIII in a liquid culture medium under supply of air enriched in carbon dioxide
有权
在含有二氧化碳的空气供应下，在液体培养基中生产胸膜肺炎放线芽孢杆菌毒素APXI或APXIII的方法
- Patent Title: Process for the production of the Actinobacillus pleuropneumoniae toxins APXI or APXIII in a liquid culture medium under supply of air enriched in carbon dioxide
- Patent Title (中): 在含有二氧化碳的空气供应下，在液体培养基中生产胸膜肺炎放线芽孢杆菌毒素APXI或APXIII的方法
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Application No.: US13131121Application Date: 2009-11-25
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Publication No.: US08445235B2Publication Date: 2013-05-21
- Inventor: Simen-Jan Slagman , Christian Theodoor Gerardus Smits
- Applicant: Simen-Jan Slagman , Christian Theodoor Gerardus Smits
- Applicant Address: NL Boxmeer
- Assignee: Intervet International B.V.
- Current Assignee: Intervet International B.V.
- Current Assignee Address: NL Boxmeer
- Priority: EP08105880 20081127
- International Application: PCT/EP2009/065797 WO 20091125
- International Announcement: WO2010/060916 WO 20100603
- Main IPC: C12P21/04
- IPC: C12P21/04
Abstract:
The current invention pertains to a method to produce RTX-toxins ApxI or ApxIII by culturing Actinobacillus pleuropneumoniae bacteria in a liquid culturing medium that supports growth of the bacteria, characterized in that air is passed through the medium, wherein the air has a carbon dioxide content above normal atmospheric level to increase RTX-toxin production during the production phase of the RTX-toxins.
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