Invention Grant
US08444983B2 Composition of anti-ENDO180 antibodies and methods of use for the treatment of cancer and fibrotic diseases
有权
抗ENDO180抗体的组成和用于治疗癌症和纤维化疾病的方法
- Patent Title: Composition of anti-ENDO180 antibodies and methods of use for the treatment of cancer and fibrotic diseases
- Patent Title (中): 抗ENDO180抗体的组成和用于治疗癌症和纤维化疾病的方法
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Application No.: US13255214Application Date: 2010-03-23
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Publication No.: US08444983B2Publication Date: 2013-05-21
- Inventor: Elena Feinstein
- Applicant: Elena Feinstein
- Applicant Address: US CA Fremont
- Assignee: Quark Pharmaceuticals, Inc.
- Current Assignee: Quark Pharmaceuticals, Inc.
- Current Assignee Address: US CA Fremont
- Agency: Cooper & Dunham LLP
- Agent John P. White
- International Application: PCT/US2010/028200 WO 20100323
- International Announcement: WO2010/111198 WO 20100930
- Main IPC: A61K51/10
- IPC: A61K51/10 ; A61K49/16 ; A61K39/395 ; A61K39/44
Abstract:
The present invention provides antibodies or antigen-binding fragments thereof that specifically bind the ENDO180 polypeptide and are internalized thereby, to conjugates comprising the molecules, to compositions comprising the antibodies and conjugates and to methods of using the same for delivery of therapeutic agents to cells that express the ENDO180 polypeptide on the surface of the cell for treating cell proliferative diseases or disorders and fibrosis, and for controlling (modulating) tumor progression.
Public/Granted literature
- US20120114704A1 COMPOUNDS, COMPOSITIONS AND METHODS OF TREATING CANCER AND FIBROTIC DISEASES Public/Granted day:2012-05-10
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