A wireless device includes an antenna, Radio Frequency (RF) circuitry, and baseband processing circuitry. The baseband processing circuitry couples to the RF circuitry and is operable to determine operational calibrations settings that may include pre-distortion characteristics and RF signal path settings, both of which are determined via calibration operations. The calibration operations are initiated when an operational value of the wireless device compares unfavorably to at least one operational threshold. Monitoring circuitry coupled to the RF circuitry and to the baseband processing circuitry monitors operational characteristics of the RF circuitry. Calibration operations may be initiated based upon RF circuitry temperature, supply voltage, PA current, PA gain input level/average, among other triggers.