Invention Grant
US08436200B2 Process for making (R)-3-(2,3-dihydroxypropyl)-6-fluoro-5-(2-flouro-4- iodophenylamino)-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione and intermediates thereof
有权
制备（R）-3-（2,3-二羟基丙基）-6-氟-5-（2-氟-4-碘苯基氨基）-8-甲基吡啶并[2,3-d]嘧啶-4,7（3H ，8H） - 二酮及其中间体
![Process for making (R)-3-(2,3-dihydroxypropyl)-6-fluoro-5-(2-flouro-4- iodophenylamino)-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione and intermediates thereof](/docs/US/2013-05-07/US08436200B2/abs.jpg.600x600.jpg)
- Patent Title: Process for making (R)-3-(2,3-dihydroxypropyl)-6-fluoro-5-(2-flouro-4- iodophenylamino)-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione and intermediates thereof
- Patent Title (中): 制备（R）-3-（2,3-二羟基丙基）-6-氟-5-（2-氟-4-碘苯基氨基）-8-甲基吡啶并[2,3-d]嘧啶-4,7（3H ，8H） - 二酮及其中间体
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Application No.: US13421421Application Date: 2012-03-15
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Publication No.: US08436200B2Publication Date: 2013-05-07
- Inventor: David Paul Provencal , Yuxin Zhao , Todd Miller , Jonathon S. Salsbury
- Applicant: David Paul Provencal , Yuxin Zhao , Todd Miller , Jonathon S. Salsbury
- Applicant Address: JP Osaka
- Assignee: Takeda Pharmaceutical Company Limited
- Current Assignee: Takeda Pharmaceutical Company Limited
- Current Assignee Address: JP Osaka
- Agent David M. Stemerick; Mitchell R. Brustein
- Main IPC: C07C69/74
- IPC: C07C69/74
![Process for making (R)-3-(2,3-dihydroxypropyl)-6-fluoro-5-(2-flouro-4- iodophenylamino)-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione and intermediates thereof](/abs-image/US/2013/05/07/US08436200B2/abs.jpg.150x150.jpg)
Abstract:
The present invention relates generally to processes of making (R)-3-(2,3-Dihydroxypropyl)-6-fluoro-5-(2-fluoro-4-iodophenylamino)-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione, intermediates thereof, and a process for making a particular polymorph of (R)-3-(2,3-Dihydroxypropyl)-6-fluoro-5-(2-fluoro-4-iodophenylamino)-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione.
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