Invention Grant
- Patent Title: Cyclohexyl-azetidinyl antagonists of CCR2
- Patent Title (中): CCR2的环己基 - 氮杂环丁烷基拮抗剂
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Application No.: US13156450Application Date: 2011-06-09
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Publication No.: US08436023B2Publication Date: 2013-05-07
- Inventor: Xuqing Zhang , Zhihua Sui , James C. Lanter
- Applicant: Xuqing Zhang , Zhihua Sui , James C. Lanter
- Applicant Address: BE
- Assignee: Janssen Pharmaceutica N.V.
- Current Assignee: Janssen Pharmaceutica N.V.
- Current Assignee Address: BE
- Agent Mary A. Appollina
- Main IPC: A61K31/4418
- IPC: A61K31/4418 ; A61K31/427 ; A61K31/422 ; A61K31/423 ; A61K31/416 ; A61K31/4178 ; C07D231/56 ; C07D401/14 ; C07D417/14 ; C07D263/32 ; C07D261/20 ; C07D233/64
Abstract:
The present invention comprises compounds of Formula (I). wherein: R1, R2, X, and Z are as defined in the specification. The invention also comprises a method of preventing, treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is type II diabetes, obesity and asthma. The invention also comprises a method of inhibiting CCR2 activity in a mammal by administration of a therapeutically effective amount of at least one compound of Formula (I).
Public/Granted literature
- US20110306592A1 CYCLOHEXYL-AZETIDINYL ANTAGONISTS OF CCR2 Public/Granted day:2011-12-15
Information query
IPC分类:
