Invention Grant
US08436006B2 2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE)
有权
可用作β-分泌酶（BACE）抑制剂的2-氨基 - 喹唑啉衍生物
- Patent Title: 2-amino-quinazoline derivatives useful as inhibitors of β-secretase (BACE)
- Patent Title (中): 可用作β-分泌酶（BACE）抑制剂的2-氨基 - 喹唑啉衍生物
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Application No.: US11197615Application Date: 2005-08-04
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Publication No.: US08436006B2Publication Date: 2013-05-07
- Inventor: Francois Paul Bischoff , Mirielle Braeken , Serge Maria Aloysius Pieters , Mark Hubert Mercken , Hans Louis Jos De Winter , Didier Jean-Claude Berthelot
- Applicant: Francois Paul Bischoff , Mirielle Braeken , Serge Maria Aloysius Pieters , Mark Hubert Mercken , Hans Louis Jos De Winter , Didier Jean-Claude Berthelot
- Applicant Address: BE Beerse
- Assignee: Jansssen Pharmaceutica N.V.
- Current Assignee: Jansssen Pharmaceutica N.V.
- Current Assignee Address: BE Beerse
- Agent Hal B. Woodrow
- Main IPC: A61K31/517
- IPC: A61K31/517 ; C07D239/94 ; A61P25/28
Abstract:
The present invention is directed to novel 2-amino-3,4-dihydro-quinazoline derivatives, pharmaceutical compositions containing them and their use in the treatment of Alzheimer's disease (AD) and related disorders. The compounds of the invention are inhibitors of β-secretase, also known as β-site cleaving enzyme and BACE.
Public/Granted literature
- US20060178383A1 Novel 2-amino-quinazoline derivatives useful as inhibitors of beta-secretase (BACE) Public/Granted day:2006-08-10
Information query
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